I never felt comfortable running in "normal runners". I don't get full control in my run, with all the paddings and rigid front side of my foot. So until very recently, i decided to get my first pair of Vibram Five Fingers (aka VFF) and test things out. 

This is the one i got, Komodo Sport VFF. If you are interested, go to a shop that sells official VFF, get measured to get the right fitting. Unless you plan to consistent run marathons with it, you probably do not need to get those special five-toes-socks. VFFs are machine washable as well.

Even with conventional runners, i run mostly on my forefoot instead of my heels, resulting in faster strides for me (its like sprinting) but much more stress on my calf muscles. I have much smaller thigh muscles in comparison to my calf. 

When i got my new pair of VFF, i went for a run along a canal, concrete like surface. i ran for about 3.5km straight on a much faster time than i am used to. It felt great. The next day, i could feel severe pain in my calf muscles, making it almost impossible to sit down and take a dump, and going down stairs. A little more than week now, and i still feel the strain (have since ran about 4-5 times in that week) on my calves. I got curious and went about searching for more explanations on why this is happening. There are lots of good articles and blog posts explaining things from running barefoot and body postures and the evolution of running methods.

These are the two most informative pieces i've found: Barefoot Running, Forefoot Striking and Running Tips and Time Ferris's writeup.

From VFF's official site, these are the things to look out for while trying on your first pair of VFF:

• Run no more than 10% of your typical running distance for the first 2–3 weeks.
• After 2–3 weeks, gradually increase mileage by 10%–20% every couple of weeks
  
• If you ever start to feel pain during a run, stop! You can always try again in a couple of days
  
• Never run 2 days in a row for the first month
  
• Stretch before and after each run, focusing on calves and feet, because Vibram FiveFingers running will stimulate these muscles
  
• If, after several weeks of training, you are consistently very sore, you need to rest and back-off on your mileage
  

Hmmm, contemplating if i should get another pair...